It is a synthetic analog of a naturally occurring substance in the human body called tuftsin. Tuftsin binds different types of white blood cells to help create an immunostimulatory effect. This effect helps our body fight off various pathogens and even kill tumor cells.
However, Selank posses many cognitive enhancing properties like another peptide related drug, Semax. Selank binds to the GABA receptors. This could explain the learning and memory enhancement sometimes reported by users. Animal studies have produced promising results in alleviating depression and anhedonia.
This includes the chemicals dopamine and serotonin. The most amazing study I was able to find on Selank, related to repairing brain damage. A study done on mice demonstrated their brains returning to normal after toxin induced brain damage. This study is definitely worth a look over. This compound has an extremely low rate of toxicity and most claim that it is side effect free.
However, I was able to find some rare online claims of temporary fatigue at excessively high dosages. You have probably seen Selank as a nasal spray product or as a lyophilized freeze dried powder. The glass vials will have a small disc inside where the peptide has basically been freeze-dried to ensure stability.
This makes it easier to reconstitute the powder with bacteriostatic water, to make the peptide become active again. But you will need to put your solution in a refrigerator for future use to ensure quality.
The common dosages for subcutaneous administration was a sweet spot between mcg and mcg. Most people claim the anti-anxiety benefits to occur at the the lower dosing. And the other cognitive traits to become present at the higher dosing. You should only dose selank once daily for 10 days at a time, to prevent building a tolerance to the compound. BiohackingNootropicsPeptidesSupplements.
Withstand Kratom Withdrawal with Selank and Memantine
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Social Media Crap Instagram Facebook. Follow Us Instagram Facebook.Kratom users describe the withdrawals as uncomfortable but not excruciating typically for 2 -5 days but sometimes as much as a month. Withdrawal symptoms can include things like irritability, restlessness, anxiety, cough, depression, etc. The majority of the anecdotal cases of negative withdrawals are from people using between 15 — 30 grams daily which seems like a pretty extreme dosage.
These people should not be so surprised that there are consequences for that kind of excess. A better solution to sustainable Kratom usage is tapering down or off Kratom every couple of months. Your dosage will inevitably creep up — when it does do like a day taper; every day take a quarter gram less of Kratom.
I did not nor would I recommend that people use Kratom everyday; I cycled Kratom with other Nootropics; using it times a week. I did not find myself impulsively using it and did not experience any withdrawal symptoms at all when I ran out.
From a 12 week, placebo controlled chinese study that gave Memantine to 53 Methadone addicts. It concluded. We conclude that low-dose memantine might be a feasible adjuvant therapy for attenuating inflammation and inhibiting methadone tolerance. From a placebo controlled study of heroin addicts. Memantine attenuated the expression of opioid physical dependence in humans, indicating that glutamatergic neurotransmission at the NMDA receptor site contributes to the maintenance of opioid dependence.
This finding suggests that memantine may be a useful adjunct in the treatment of opioid dependence. One Kratom lover reported enthusiastically. Since I have started doing this, all my Kratom has more of a stimulant edge. There is not a ton of added jitteriness or anxiety, but rather the get and go effects of each strain are more prominent. Used to when I took 2.
Now when I take this dose, I have the urge to physically get up and get my body moving and exercise, do yard work, etc…. If you want stronger effects from your kratom, or you need to reduce your tolerance, I recommend memantine. This anxiolytic Russian peptide will likely give you more bang for your buck from your Kratom. A study of 70 Russians found that it markedly decreased the negative side effects of the opioid.
The combined treatment decreased the level of undesirable side-effects of phenazepam attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism during the course of treatment and after the tranquilizer withdrawal. Taken together, the therapeutic efficacy and reduction of side-effects had a positive impact on the quality-of-life of the patients treated with selank as add-on to phenazepam.Selank is one of the rising nootropics today.
What is it exactly, and what are its potential benefits?
WHAT IS SELANK AND WHAT ARE THE POTENTIAL BENEFITS OF TAKING IT?
Disclaimer: The purpose of this post is to present medical studies and information in an accessible manner. This post may contain opinions about this particular drug but it does not mean that it is recommended for all readers. Always consult a medical professional to see if these solutions may be right for you.
Selank, also known as TP-7, is a synthetic peptide derived by combining the sequence of tuftsin with another sequence to improve its stability. Tuftsin makes up one part of the IgG antibody and is naturally occurring. Tuftsin Definition: A peptide closely related to the immune function primarily supported by the spleen. On top of its immunity boosting, anti-anxietyantidepressant, and antiasthenic properties, it can also enhance memory and cognitive function.
This peptide can potentially replace stimulants, tranquilizers, and antidepressants. Another research also reported it to have been able to change levels of serotonin, dopamine, and norepinephrine, the neurotransmitters involved in motivation, focus, and pleasure. Selank is an anxiolytic peptide, which helps combat stress and anxiety. As a general rule, you should never take any peptide or medication other than what your physician prescribed.
The subjects treated with the peptide learned quicker on an electrical test. In a day trial in rats, Selank showed to have stabilized memory traces in rats. Researchers found Selank to restore the brain activity of mice with toxin-induced brain damage to normal levels.
A study in mice showed that injecting the stressed subjects with Selank increase the levels of antioxidants in their livers. In one study, Selank increased blood IL-6, an inflammatory protein that can help fight infection, levels of depression patients. A different cell-based study found that Selank induced the release of the anti-viral molecules interferons. In this study, it did not show any treatment effect in virus-infected mice. It found out that Selank decreased alcohol-withdrawal-related anxiety of the rats after a hour period.Selank development was directed by Myasoedov N.
Myasoedov Nikolai Fyodorovich born October 31, According to Decree no. Author of the first Russian manuals including Molecular Biology, NeurochemistryThe biochemistry of the brain ; over scientific papers and monographs.
In I. Asmarin and a team of authors were awarded Russian Federation Government Award for development, manufacturing process management and introduction of the drug into clinical practice. Address: Russian Federation, Moscow, 2 pl. Akademika Kurchatova St. Improves nervous system activity, recovers balance in cerebral emotional areas facilitating getting through stress, anxiety and depression. Efficient protection. Smart and advanced. Studied and accepted. Common use. Intranasal administration is the most effective administration route for drugs improving brain activity.
Therefore, nasal instillation along the olfactory nerves induces direct delivery to brain tissue. What are these drugs?
They include polypeptides i. Since Selank is a polypeptide, it is delivered to brain through olfactory nerves in just a few minutes. This fact determines rapid therapeutic effect. That is why, most of them do not reach the brain and only small amount is delivered to it. Also, it should be considered that intranasal administration is not associated with any inconveniences for a patient or special procedures performed by qualified personnel.
Even in several minutes after contact with mucosa Selank action begins to help brain cells. Selank provides fast recovery and getting on with usual activity which are critical factors for everyone. Depression is a severe psycho-emotional disorder. Depressed person suffers from hard rankling emotions and experience i.
Will activity and self-rating are sharply decreased. Additionally, a patient feels futility of existence. The hardest psychiatric issue is depression treatment aimed to drive a patient out of this state.It is a synthetic analogue of human tuftsin. Selank is a synthetic analogue of the immunomodulatory peptide tuftsin ; as such, it mimics many of its effects.
It has been shown to modulate the expression of Interleukin-6 IL-6 and affect the balance of T helper cell cytokines. Selank, as well as a related peptide drug, Semaxhave been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptidesand this action may be involved in their effects. Selank has been found to produce antidepressant -like effects in animal models of depression and anhedonia.
In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment of generalized anxiety disorder GAD. Selank is closely related to another nootropic drug, Semaxalso developed by the Institute of Molecular Genetics in Russia.
This drug is currently available in Russian and Ukrainian pharmacies. As with all lyophilized peptides, it needs refrigeration to remain stable within sterile water solutions, such as bacteriostatic water concentrations. From Wikipedia, the free encyclopedia. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
IUPAC name. Interactive image. Zhurnal Nevrologii i Psikhiatrii Imeni S. Eksperimental'naia i klinicheskaia farmakologiia. Doklady Biological Sciences. Anxiolytics N05B. Gabapentin Gabapentin enacarbil Phenibut Pregabalin. SSRIs e. Alpha-1 blockers e. See here instead. Antagonists: Nastorazepide.
Propeptides: Preproglucagon Proglucagon. Agonists: Kisspeptin Kisspeptin Antagonists: Kisspeptin Agonists: Leptin Metreleptin. Agonists: Melanin-concentrating hormone. Agonists: Insulin-like factor 3 Relaxin 123 Serelaxin. Agonists: Thyrotropin alfa TSH thyrotropin.
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Selank: Rapid response to stress and modulation of emotion
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